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While multinational companies develop meta-level policies to address grand sustainability challenges and CEOs are increasingly showing their social activism, the hard work of concretely defending communities’ rights and the environment from business exploitation is often left to powerless individuals, known as human rights defenders (here defenders), who face severe risks for their advocacy. According to some statistics, between 2015 and 2022, defenders worldwide have been subject to over 4,000 attacks, including killings, tortures, and intimidation. In this chapter, the authors discuss the relevance of defenders to the promotion of the sustainable development goal (SDG) agenda and develop a conceptual model to predict CEOs’ reactions to defenders.

A cascade of crises that materialized in particular over the 2019–2022 period, increases the relevance for international business (IB) scholarship to address the following question: whether, to what extent and under what circumstances can multinational enterprises (MNEs) rescue the sustainable development goals (SDGs) and make sure that nobody is left behind in a globalized world where the opposite seems to be the case? For many MNEs, slow progress in implementing the SDGs in a more strategic and transformational manner does not necessarily hint at a lack of interest with management, but also at a lack of solid knowledge and/or experience in how to implement general development ambitions like the SDGs. This introductory chapter defines the intellectual and managerial challenges ahead. It refers to relevant efforts already done in the IB community – with reference to IB journals that issued special editions on the topic – and explains why five angles have been chosen to cluster the contributions in this volume which are also aimed to enhance further progress in the study of MNEs and the SDGs: (1) general, (2) strategic, (3) operational, (4) contextual and (5) misbehavior.